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Meeker, J. E.; Som, C. W.; Macapagal, E. C.; Benson, P. A.
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Zolpidem tissue concentrations in a multiple drug related death involving AmbienŽ | Title |
J Anal Toxicol 1995, 19(6), 531-534
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| Zolpidem, Combined poisoning, Analytical findings
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| Zolpidem, a relatively new nonbenzodiazepine sedative- hypnotic, was involved in the death of a 39-year-old obese male who was being treated for depression and insomnia. The identification and quantitation procedures of zolpidem in postmortem tissues included dual-column gas chromatography (GC) with nitrogen-phosphorus detection and GC-mass spectrometry. Zolpidem was present at concentrations of 2.91, 1.40, and 2.13 mug/mL in the heart blood, peripheral blood, and urine, respectively. The liver had zolpidem present at a concentration of 4.74 mug/g, and the gastric contents had a total of 172 mg zolpidem. Additional drugs present included hydrocodone and morphine (nonconjugated) at 0.16 and 0.04 mug/mL, respectively. The cause of death was determined to be multiple drug intoxication. This report describes the analytical techniques and significance of the zolpidem findings.
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