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Manos GH
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Possible serotonin syndrome associated with buspirone added to fluoxetine. | Title |
Ann Pharmacother 2000 Jul-Aug;34(7-8):871-4
| Source |
| Fluoxetine, Buspirone, Serotonin syndrome, Interaction, Adverse drug reactions
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| OBJECTIVE: To report the development of a possible serotonin syndrome in a patient taking buspirone and fluoxetine.
CASE SUMMARY: A 37-year-old white man taking fluoxetine 20 mg/d for generalized anxiety disorder developed confusion, diaphoresis, incoordination, diarrhea, and myoclonus after buspirone was added to the drug regimen.
DISCUSSION: Serotonin syndrome is a potentially lethal condition of serotonin hyperstimulation, which may develop rapidly or over the course of several weeks. Symptoms of serotonin syndrome typically occur following additions or increases of serotonin-enhancing drugs. Although buspirone has variable effects on post- and presynaptic 5-HT1A receptors that may reduce the risk of serotonin syndrome when administered as a single agent, it may cause an adverse reaction when given with other serotonergic drugs.
CONCLUSIONS: Symptoms consistent with serotonin syndrome may develop with the concurrent administration of buspirone and fluoxetine.
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