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Machijima, H.; Nakamura, H.; Hatanaka, T.; Sugibayashi, K.; Morimoto, Y.
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Effect of several adsorbents on the gastrointestinal absorption of paraquat | Title |
Arch Pharmacal Res 1994, 17(5), 287-293
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| Paraquat, Decontamination, primary, Charcoal
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| The effect of several adsorbents on paraquat poisoning was investigated (1) by measuring the saturated amount of the poison adhered on the adsorbents in vitro and (2) by assaying the blood level of paraquat in the rat in in situ intestinal absorption experiments. Activated charcoal powder, natural aluminum silicate, and cationic exchange resins (calcium polystyrene sulfonate and sodium polystyrene sulfonate) were used as adsorbents. The steady- state blood level of paraquat in its absorption experiment with the cationic exchange resins was markedly lower than those without the resins or with other adsorbents. A good relationship was achieved between the calculated AUC or absorption rate (in situ) and the saturated adsorption amount (in vitro). The rank order of the effect was sodium polystyrene sulfonate > calcium polystyrene sulfonate > natural aluminum silicate > activated charcoal powder. The effect of sodium polystyrene sulfonate after intestinal washing with physiological saline was also measured, and a synergistic effect (marked decrease in blood paraquat level) was found as compared with the intestinal washing alone. The simultaneous use of G.I. washing and powerful adsorbent was scientifically proven to be most beneficial.
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