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Macfarlane, B.; Davies, S.; Mannan, K.; Sarsam, R.; Pariente, D.; Dooley, J.
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Fatal acute fulminant liver failure due to clozapine: a case report and review of clozapine-induced hepatotoxicity | Title |
Gastroenterology 1997, 112(5), 1707-1709
| Source |
| Clozapine, Adverse drug reactions, Hepatotoxicity, Fatal outcome
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| Clozapine-induced hepatotoxicity is not well known and is usually of no clinical significance. This report describes fatal acute fulminant liver failure caused by clozapine in a 39-year-old man with chronic paranoid schizophrenia. The hepatotoxicity of clozapine is reviewed. Asymptomatic elevation of transaminase levels is observed most commonly, affecting between 30% and 50% of patients. Icteric hepatitis is uncommon, noted in 84 of 136,000 patients (0.06%). Fatal acute fulminant hepatitis has been documented in 2 patients (0.001%). The mechanism of clozapine hepatotoxicity is unknown. Although serious toxicity is rare, prescribers of clozapine should be aware of the hepatotoxic potential. Author.
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